KCNK9
From Wikipedia, the free encyclopedia
| Potassium channel, subfamily K, member 9 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KCNK9; K2p9.1; KT3.2; MGC138268; MGC138270; TASK-3; TASK3 | ||||||||||||
| External IDs | OMIM: 605874 MGI: 3521816 HomoloGene: 56758 IUPHAR: K2P9.1 GeneCards: KCNK9 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 51305 | 223604 | |||||||||||
| Ensembl | ENSG00000169427 | ENSMUSG00000036760 | |||||||||||
| UniProt | Q9NPC2 | Q3LS21 | |||||||||||
| RefSeq (mRNA) | NM_016601 | NM_001033876.1 | |||||||||||
| RefSeq (protein) | NP_057685 | NP_001029048.1 | |||||||||||
| Location (UCSC) | Chr 8: 140.61 – 140.72 Mb |
Chr 15: 72.34 – 72.38 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Potassium channel subfamily K member 9 is a protein that in humans is encoded by the KCNK9 gene.[1][2][3]
This gene encodes K2P9.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is highly expressed in the cerebellum. It is inhibited by extracellular acidification and arachidonic acid, and strongly inhibited by phorbol 12-myristate 13-acetate.[3] Phorbol 12-myristate 13-acetate is also known as 12-O-tetradecanoylphorbol-13-acetate (TPA).
Contents |
[edit] Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [4]
[edit] See also
[edit] References
- ^ Kim Y, Bang H, Kim D (May 2000). "TASK-3, a new member of the tandem pore K(+) channel family". J Biol Chem 275 (13): 9340–7. doi:10.1074/jbc.275.13.9340. PMID 10734076.
- ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
- ^ a b "Entrez Gene: KCNK9 potassium channel, subfamily K, member 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51305.
- ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". http://www.wikipathways.org/index.php/Pathway:WP1602.
[edit] Further reading
- Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits.". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
- Rajan S, Wischmeyer E, Xin Liu G, et al. (2000). "TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor.". J. Biol. Chem. 275 (22): 16650–7. doi:10.1074/jbc.M000030200. PMID 10747866.
- Chapman CG, Meadows HJ, Godden RJ, et al. (2001). "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel.". Brain Res. Mol. Brain Res. 82 (1–2): 74–83. doi:10.1016/S0169-328X(00)00183-2. PMID 11042359.
- Vega-Saenz de Miera E, Lau DH, Zhadina M, et al. (2001). "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1". J. Neurophysiol. 86 (1): 130–42. PMID 11431495.
- Talley EM, Bayliss DA (2002). "Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action". J. Biol. Chem. 277 (20): 17733–42. doi:10.1074/jbc.M200502200. PMID 11886861.
- Rajan S, Preisig-Müller R, Wischmeyer E, et al. (2003). "Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3". J. Physiol. (Lond.) 545 (Pt 1): 13–26. doi:10.1113/jphysiol.2002.027052. PMC 2290646. PMID 12433946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2290646.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Mu D, Chen L, Zhang X, et al. (2003). "Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene". Cancer Cell 3 (3): 297–302. doi:10.1016/S1535-6108(03)00054-0. PMID 12676587.
- Pei L, Wiser O, Slavin A, et al. (2003). "Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7803–7. doi:10.1073/pnas.1232448100. PMC 164668. PMID 12782791. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164668.
- Rusznák Z, Pocsai K, Kovács I, et al. (2004). "Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum". Cell. Mol. Life Sci. 61 (12): 1532–42. doi:10.1007/s00018-004-4082-3. PMID 15197476.
- Clarke CE, Veale EL, Green PJ, et al. (2005). "Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc". J. Physiol. (Lond.) 560 (Pt 1): 51–62. doi:10.1113/jphysiol.2004.070292. PMC 1665210. PMID 15284350. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1665210.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Kim CJ, Cho YG, Jeong SW, et al. (2005). "Altered expression of KCNK9 in colorectal cancers". APMIS 112 (9): 588–94. doi:10.1111/j.1600-0463.2004.apm1120905.x. PMID 15601307.
- Pocsai K, Kosztka L, Bakondi G, et al. (2006). "Melanoma cells exhibit strong intracellular TASK-3-specific immunopositivity in both tissue sections and cell culture". Cell. Mol. Life Sci. 63 (19–20): 2364–76. doi:10.1007/s00018-006-6166-8. PMID 17013562.
- Zuzarte M, Rinné S, Schlichthörl G, et al. (2007). "A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3". Traffic 8 (8): 1093–100. doi:10.1111/j.1600-0854.2007.00593.x. PMID 17547699.
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