KCNMB1

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Potassium large conductance calcium-activated channel, subfamily M, beta member 1
Identifiers
Symbols KCNMB1 ; BKbeta1; K(VCA)beta; SLO-BETA; hbeta1; hslo-beta; k(VCA)beta-1; slo-beta-1
External IDs OMIM603951 MGI1334203 HomoloGene3054 ChEMBL: 5078 GeneCards: KCNMB1 Gene
RNA expression pattern
PBB GE KCNMB1 209948 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3779 16533
Ensembl ENSG00000145936 ENSMUSG00000020155
UniProt Q16558 Q8CAE3
RefSeq (mRNA) NM_004137 NM_031169
RefSeq (protein) NP_004128 NP_112446
Location (UCSC) Chr 5:
169.8 – 169.82 Mb
Chr 11:
33.96 – 33.97 Mb
PubMed search [1] [2]

Calcium-activated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNMB1 gene.[1][2][3]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits.[3]

See also[edit]

References[edit]

  1. ^ Tseng-Crank J, Godinot N, Johansen TE, Ahring PK, Strobaek D, Mertz R, Foster CD, Olesen SP, Reinhart PH (Oct 1996). "Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain". Proc. Natl. Acad. Sci. U.S.A. 93 (17): 9200–5. doi:10.1073/pnas.93.17.9200. PMC 38619. PMID 8799178. 
  2. ^ Jiang Z, Wallner M, Meera P, Toro L (Mar 1999). "Human and rodent MaxiK channel beta-subunit genes: cloning and characterization". Genomics 55 (1): 57–67. doi:10.1006/geno.1998.5627. PMID 9888999. 
  3. ^ a b "Entrez Gene: KCNMB1 potassium large conductance calcium-activated channel, subfamily M, beta member 1". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.