KCNN2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Protein KCNN2 PDB 1g4y.png
PDB rendering based on 1g4y.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KCNN2 ; KCa2.2; SK2; SKCA2; hSK2
External IDs OMIM605879 MGI2153182 HomoloGene23150 IUPHAR: KCa2.2 ChEMBL: 4469 GeneCards: KCNN2 Gene
RNA expression pattern
PBB GE KCNN2 220116 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3781 140492
Ensembl ENSG00000080709 ENSMUSG00000054477
UniProt Q9H2S1 P58390
RefSeq (mRNA) NM_021614 NM_080465
RefSeq (protein) NP_067627 NP_536713
Location (UCSC) Chr 5:
113.7 – 113.83 Mb
Chr 18:
45.27 – 45.69 Mb
PubMed search [1] [2]

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, also known as KCNN2, is a protein which in humans is encoded by the KCNN2 gene.[1] KCNN2 is an ion channel protein also known as KCa2.2.[2]

Function[edit]

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The KCa2.2 protein is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. KCa2.2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the calcium-activated potassium channel family. Two transcript variants encoding different isoforms have been found for the KCNN2 gene.[2]

In a study SK2 (KCNN2) potassium channel was overexpressed in the basolateral amygdala using a herpes simplex viral system. This reduced anxiety and stress-induced corticosterone secretion at a systemic level. SK2 overexpression also reduced dendritic arborization of the amygdala neurons.[3]

See also[edit]

References[edit]

  1. ^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (December 2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. 
  2. ^ a b "Entrez Gene: KCNN2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2". 
  3. ^ Mitra R, Ferguson D, Sapolsky RM (February 2009). "SK2 potassium channel over-expression in basolateral amygdala reduces anxiety, stress-induced corticosterone and dendritic arborization". Mol. Psychiatry 14 (9): 847–55, 827. doi:10.1038/mp.2009.9. PMC 2763614. PMID 19204724. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.