KCNN4

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Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Identifiers
Symbols KCNN4 ; IK1; IKCA1; KCA4; KCa3.1; SK4; hIKCa1; hKCa4; hSK4
External IDs OMIM602754 MGI1277957 HomoloGene1696 IUPHAR: KCa3.1 ChEMBL: 4305 GeneCards: KCNN4 Gene
RNA expression pattern
PBB GE KCNN4 204401 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3783 16534
Ensembl ENSG00000104783 ENSMUSG00000054342
UniProt O15554 O89109
RefSeq (mRNA) NM_002250 NM_001163510
RefSeq (protein) NP_002241 NP_001156982
Location (UCSC) Chr 19:
44.27 – 44.29 Mb
Chr 7:
24.37 – 24.39 Mb
PubMed search [1] [2]

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.[1]

Function[edit]

The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane depolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[1]

History[edit]

The channel activity was first described in 1958 by Gyorgi Gardos in human erythrocytes.[2] The channels is also named Gardos channel because of its discoverer.

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4". 
  2. ^ Gardos G (1958). "The function of calcium in the potassium permeability of human erythrocytes". Biochim. Biophys. Acta 30 (3): 653–4. doi:10.1016/0006-3002(58)90124-0. PMID 13618284. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.