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KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
Symbols KCNQ1OT1 ; KCNQ1-AS2; KCNQ10T1; KvDMR1; KvLQT1-AS; LIT1; NCRNA00012
External IDs OMIM604115 GeneCards: KCNQ1OT1 Gene
Species Human Mouse
Entrez 10984 n/a
Ensembl ENSG00000269821 n/a
UniProt n/a n/a
RefSeq (mRNA) NR_002728 n/a
RefSeq (protein) n/a n/a
Location (UCSC) Chr 11:
2.63 – 2.72 Mb
PubMed search [1] n/a

KCNQ1 overlapping transcript 1, also known as KCNQ1OT1, is a long non-coding RNA gene found in the KCNQ1 locus. This locus consists of 8-10 protein-coding genes, specifically expressed from the maternal allele (including the KCNQ1 gene), and the paternally expressed non-coding RNA gene KCNQ1OT1.[1] KCNQ1OT1 is a nuclear, 91 kb transcript, found in close proximity to the nucleolus in certain cell types.[2][3]

It interacts with chromatin, the histone methyltransferase G9a (responsible for the mono- and dimethylation of histone 3 lysine 9, H3K9), and the Polycomb Repressive Complex 2, PRC2, (responsible for the trimethylation of H3K27).[2] It plays an important role in the transcriptional silencing of the KCNQ1 locus by regulating histone methylation.[1] An 890 bp region at the 5' end of KCNQ1OT1 acts as a silencing domain.[4][5] This region regulates CpG methylation levels of somatically acquired differentially methylated regions (DMRs), mediates the interaction of KCNQ1OT1 with chromatin and with DNA (cytosine-5)-methyltransferase 1 (DNMT1), but does not affect the interactions of histone methyltransferases with KCNQ1OT1.[5]

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  1. ^ a b Kanduri C (February 2011). "Kcnq1ot1: A chromatin regulatory RNA". Semin Cell Dev Biol 22 (4): 343–50. doi:10.1016/j.semcdb.2011.02.020. PMID 21345374. 
  2. ^ a b Pandey RR, Mondal T, Mohammad F, Enroth S, Redrup L, Komorowski J, Nagano T, Mancini-Dinardo D, Kanduri C (October 2008). "Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation". Mol. Cell 32 (2): 232–46. doi:10.1016/j.molcel.2008.08.022. PMID 18951091. 
  3. ^ Fedoriw AM, Calabrese JM, Mu W, Yee D, Magnuson T (December 2012). "Differentiation-driven nucleolar association of the mouse imprinted Kcnq1 locus.". G3 2 (12): 1521–8. doi:10.1534/g3.112.004226. PMID 23275875. 
  4. ^ Mohammad F, Pandey RR, Nagano T, Chakalova L, Mondal T, Fraser P, Kanduri C (June 2008). "Kcnq1ot1/Lit1 noncoding RNA mediates transcriptional silencing by targeting to the perinucleolar region". Mol. Cell. Biol. 28 (11): 3713–28. doi:10.1128/MCB.02263-07. PMC 2423283. PMID 18299392. 
  5. ^ a b Mohammad F, Mondal T, Guseva N, Pandey GK, Kanduri C (August 2010). "Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1". Development 137 (15): 2493–9. doi:10.1242/dev.048181. PMID 20573698. 

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