KCNU1
From Wikipedia, the free encyclopedia
| Potassium channel, subfamily U, member 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KCNU1; KCNMC1; KCa5; KCa5.1; Kcnma3; Slo3 | ||||||||||||
| External IDs | MGI: 1202300 HomoloGene: 7392 IUPHAR: KCa5.1 GeneCards: KCNU1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 157855 | 16532 | |||||||||||
| Ensembl | ENSG00000215262 | ENSMUSG00000031576 | |||||||||||
| UniProt | A8MYU2 | O54982 | |||||||||||
| RefSeq (mRNA) | NM_001031836 | NM_008432.3 | |||||||||||
| RefSeq (protein) | NP_001027006 | NP_032458.3 | |||||||||||
| Location (UCSC) | Chr 8: 36.64 – 36.79 Mb |
Chr 8: 26.96 – 27.05 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the KCa5.1 protein.[1].
Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.[2][3][4]
[edit] References
- ^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
- ^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.". Pharmacol Rev 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.
- ^ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K+ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2151565.
- ^ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K+ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2151566.
Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).
[edit] Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Schreiber M, Wei A, Yuan A, et al. (1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes.". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
- Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8.". Nature 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
- Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.
Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).
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