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KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
Symbols KDELR2 ; ELP-1; ERD2.2
External IDs OMIM609024 HomoloGene129146 GeneCards: KDELR2 Gene
RNA expression pattern
PBB GE KDELR2 200699 at tn.png
PBB GE KDELR2 200698 at tn.png
PBB GE KDELR2 200700 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11014 66913
Ensembl ENSG00000136240 ENSMUSG00000079111
UniProt P33947 Q9CQM2
RefSeq (mRNA) NM_001100603 NM_025841
RefSeq (protein) NP_001094073 NP_080117
Location (UCSC) Chr 7:
6.49 – 6.52 Mb
Chr 5:
143.4 – 143.42 Mb
PubMed search [1] [2]

ER lumen protein retaining receptor 2 is a protein that in humans is encoded by the KDELR2 gene.[1][2][3]

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product.[3]

See also[edit]


  1. ^ Hsu VW, Shah N, Klausner RD (Jun 1992). "A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1". Cell 69 (4): 625–35. doi:10.1016/0092-8674(92)90226-3. PMID 1316805. 
  2. ^ Lewis MJ, Pelham HR (Oct 1992). "Sequence of a second human KDEL receptor". J Mol Biol 226 (4): 913–6. doi:10.1016/0022-2836(92)91039-R. PMID 1325562. 
  3. ^ a b "Entrez Gene: KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2". 

Further reading[edit]