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KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
Symbols KDELR3 ; ERD2L3
External IDs MGI2145953 HomoloGene68533 GeneCards: KDELR3 Gene
RNA expression pattern
PBB GE KDELR3 204017 at tn.png
PBB GE KDELR3 207265 s at tn.png
More reference expression data
Species Human Mouse
Entrez 11015 105785
Ensembl ENSG00000100196 ENSMUSG00000010830
UniProt O43731 Q8R1L4
RefSeq (mRNA) NM_006855 NM_134090
RefSeq (protein) NP_006846 NP_598851
Location (UCSC) Chr 22:
38.86 – 38.88 Mb
Chr 15:
79.52 – 79.53 Mb
PubMed search [1] [2]

ER lumen protein retaining receptor 3 is a protein that in humans is encoded by the KDELR3 gene.[1]

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, lys-asp-glu-leu (KDEL) in animal cells and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described.[1]

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