KDEN began broadcasting as an independent station on March 31, 1997. NBC purchased KDEN from Longmont Broadcasting in January 2006, making it NBC's second owned-and-operated station in Denver and their seventeenth Spanish-language television station. (The first NBC owned-and-operated Denver station was KCNC-TV during the late 1980s and early 1990s.) The station joined Telemundo on March 6. Before moving to KDEN, Telemundo programming was seen in Denver on low-power stations KMAS-LP and KSBS-LP, themselves repeaters of KMAS-TV from Steamboat Springs; after the purchase of KDEN, KMAS-TV was donated to Rocky Mountain PBS and became KRMZ, while KSBS-LP was sold to Denver Digital Television (KMAS-LP remains owned by NBC).
Local news cut-ins were offered during Telemundo's national newscasts until budget cuts at NBC Universal led to the segments' discontinuation in late 2006. However, on October 3, 2011, the station launched weeknight newscasts at 5:30 and 10 p.m., branded as Noticiero Telemundo Denver, produced in partnership with the NBC affiliate KUSA, from that station's studios.