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Symbols KERA ; CNA2; KTN; SLRR2B
External IDs OMIM603288 MGI1202398 HomoloGene5106 GeneCards: KERA Gene
RNA expression pattern
PBB GE KERA 220504 at tn.png
More reference expression data
Species Human Mouse
Entrez 11081 16545
Ensembl ENSG00000139330 ENSMUSG00000019932
UniProt O60938 O35367
RefSeq (mRNA) NM_007035 NM_008438
RefSeq (protein) NP_008966 NP_032464
Location (UCSC) Chr 12:
91.44 – 91.45 Mb
Chr 10:
97.61 – 97.61 Mb
PubMed search [1] [2]

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan is a protein that in humans is encoded by the KERA gene.[1][2][3]

Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.[3]

Mutations of the gene cause cornea plana 2.


  1. ^ Tasheva ES, Funderburgh JL, Funderburgh ML, Corpuz LM, Conrad GW (Jan 2000). "Structure and sequence of the gene encoding human keratocan". DNA Seq 10 (1): 67–74. doi:10.3109/10425179909033939. PMID 10565548. 
  2. ^ Pellegata NS, Dieguez-Lucena JL, Joensuu T, Lau S, Montgomery KT, Krahe R, Kivela T, Kucherlapati R, Forsius H, de la Chapelle A (Jun 2000). "Mutations in KERA, encoding keratocan, cause cornea plana". Nat Genet 25 (1): 91–5. doi:10.1038/75664. PMID 10802664. 
  3. ^ a b "Entrez Gene: KERA keratocan". 

Further reading[edit]