Keratocan

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Keratocan
Identifiers
Symbols KERA ; CNA2; KTN; SLRR2B
External IDs OMIM603288 MGI1202398 HomoloGene5106 GeneCards: KERA Gene
RNA expression pattern
PBB GE KERA 220504 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11081 16545
Ensembl ENSG00000139330 ENSMUSG00000019932
UniProt O60938 O35367
RefSeq (mRNA) NM_007035 NM_008438
RefSeq (protein) NP_008966 NP_032464
Location (UCSC) Chr 12:
91.44 – 91.45 Mb
Chr 10:
97.61 – 97.61 Mb
PubMed search [1] [2]

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan is a protein that in humans is encoded by the KERA gene.[1][2][3]

Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.[3]

Mutations of the gene cause cornea plana 2.

References[edit]

  1. ^ Tasheva ES, Funderburgh JL, Funderburgh ML, Corpuz LM, Conrad GW (Jan 2000). "Structure and sequence of the gene encoding human keratocan". DNA Seq 10 (1): 67–74. doi:10.3109/10425179909033939. PMID 10565548. 
  2. ^ Pellegata NS, Dieguez-Lucena JL, Joensuu T, Lau S, Montgomery KT, Krahe R, Kivela T, Kucherlapati R, Forsius H, de la Chapelle A (Jun 2000). "Mutations in KERA, encoding keratocan, cause cornea plana". Nat Genet 25 (1): 91–5. doi:10.1038/75664. PMID 10802664. 
  3. ^ a b "Entrez Gene: KERA keratocan". 

Further reading[edit]