CEMIP

From Wikipedia, the free encyclopedia
(Redirected from KIAA1199 (gene))
CEMIP
Identifiers
AliasesCEMIP, CCSP1, KIAA1199, TMEM2L, HYBID, cell migration inducing hyaluronan binding protein, cell migration inducing hyaluronidase 1
External IDsOMIM: 608366 MGI: 2443629 HomoloGene: 10268 GeneCards: CEMIP
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018689
NM_001293298
NM_001293304

NM_030728

RefSeq (protein)

NP_001280227
NP_001280233
NP_061159

NP_109653

Location (UCSC)Chr 15: 80.78 – 80.95 MbChr 7: 83.58 – 83.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene.[5] CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases.[6] Such function has also been validated in mice.[7]

CEMIP is associated with nonsyndromic deafness,[8] as well as a variety of cancers.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103888 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052353 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: KIAA1199 KIAA1199".
  6. ^ Yoshida H, Nagaoka A, Kusaka-Kikushima A, Tobiishi M, Kawabata K, Sayo T, Sakai S, Sugiyama Y, Enomoto H, Okada Y, Inoue S (18 March 2013). "KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization". Proceedings of the National Academy of Sciences. 110 (14): 5612–5617. Bibcode:2013PNAS..110.5612Y. doi:10.1073/pnas.1215432110. PMC 3619336. PMID 23509262.
  7. ^ Yoshida H, Nagaoka A, Nakamura S, Sugiyama Y, Okada Y, Inoue S (17 August 2013). "Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization". FEBS Open Bio. 3 (1): 352–356. doi:10.1016/j.fob.2013.08.003. PMC 3821019. PMID 24251095.
  8. ^ Abe S, Usami S, Nakamura Y (Nov 2003). "Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss". J Hum Genet. 48 (11): 564–70. doi:10.1007/s10038-003-0079-2. PMID 14577002.
  9. ^ Zhang Y, Jia S, Jiang W (20 February 2014). "KIAA1199 and its biological role in human cancer and cancer cells (Review)". Oncology Reports. 31 (4): 1503–1508. doi:10.3892/or.2014.3038. PMID 24573670.

Further reading[edit]