Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1gene.
A single nucleotide polymorphism (rs17070145) in the gene has been association with human memory performance in one 2006 study. No significant support for association with memory was found in a study with 584 subjects. However it was replicated in a smaller study of the elderly. A subsequent study in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.
KIBRA has at least 10 interaction partners, including synaptopodin, PKCζ and Dendrin, most of which modify synaptic plasticity. For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation.KIBRA has been shown to interact with Protein kinase Mζ.
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^Kremerskothen J, Plaas C, Büther K, Finger I, Veltel S, Matanis T et al. (Jan 2003). "Characterization of KIBRA, a novel WW domain-containing protein". Biochem Biophys Res Commun300 (4): 862–7. doi:10.1016/S0006-291X(02)02945-5. PMID12559952.
^Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV et al. (October 2006). "Common Kibra alleles are associated with human memory performance". Science314 (5798): 475–8. doi:10.1126/science.1129837. PMID17053149.
^Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP et al. (July 2008). "Failure to replicate effect of Kibra on human memory in two large cohorts of European origin". American Journal of Medical Genetics147B (5): 667–8. doi:10.1002/ajmg.b.30658. PMID18205171.
Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP et al. (2008). "Failure to replicate effect of kibra on human memory in two large cohorts of European origin.". American Journal of Medical Genetics147B (5): 667–8. doi:10.1002/ajmg.b.30658. PMID18205171.
Almeida OP, Schwab SG, Lautenschlager NT, Morar B, Greenop KR, Flicker L et al. (2008). "KIBRA Genetic Polymorphism Influences Episodic Memory in Later Life, but Does Not Increase the Risk of Mild Cognitive Impairment.". Journal of Cellular and Molecular Medicine12 (5A): 1672–6. doi:10.1111/j.1582-4934.2008.00229.x. PMID18194457.
Rodríguez-Rodríguez E, Infante J, Llorca J, Mateo I, Sánchez-Quintana C, García-Gorostiaga I et al. (2009). "Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk.". Neurobiol. Aging30 (2): 322–4. doi:10.1016/j.neurobiolaging.2007.07.003. PMID17707552.
Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV et al. (2006). "Common Kibra alleles are associated with human memory performance.". Science314 (5798): 475–8. doi:10.1126/science.1129837. PMID17053149.
Rayala SK, den Hollander P, Manavathi B, Talukder AH, Song C, Peng S et al. (2006). "Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.". J. Biol. Chem.281 (28): 19092–9. doi:10.1074/jbc.M600021200. PMID16684779.