KIF17

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Kinesin family member 17
Identifiers
Symbols KIF17 ; KIF17B; KIF3X; KLP-2; OSM-3
External IDs OMIM605037 MGI1098229 HomoloGene5883 GeneCards: KIF17 Gene
RNA expression pattern
PBB GE KIF17 222144 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57576 16559
Ensembl ENSG00000117245 ENSMUSG00000028758
UniProt Q9P2E2 Q99PW8
RefSeq (mRNA) NM_001122819 NM_001190978
RefSeq (protein) NP_001116291 NP_001177907
Location (UCSC) Chr 1:
20.99 – 21.04 Mb
Chr 4:
138.25 – 138.3 Mb
PubMed search [1] [2]

Kinesin-like protein KIF17 is a protein that in humans is encoded by the KIF17 gene.[1][2] KIF17 and its close relative, C. elegans OSM-3,[3] are members of the kinesin-2 family of plus-end directed microtubule-based motor proteins.[4] In contrast to heterotrimeric kinesin-2 motors,[5] however, KIF17 and OSM-3 form distinct homodimeric complexes.[6] Homodimeric kinesin-2 has been implicated in the transport of NMDA receptors along dendrites for delivery to the dendritic membrane,[1] whereas both heterotrimeric and homodimeric kinesin-2 motors function cooperatively in anterograde intraflagellar transport (IFT) and cilium biogenesis.[7][8]

References[edit]

  1. ^ a b Setou M, Nakagawa T, Seog DH, Hirokawa N (Jun 2000). "Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport". Science 288 (5472): 1796–802. doi:10.1126/science.288.5472.1796. PMID 10846156. 
  2. ^ "Entrez Gene: KIF17 kinesin family member 17". 
  3. ^ Shakir MA, Fukushige T, Yasuda H, Miwa J, Siddiqui SS (July 1993). "C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein". Neuroreport 4 (7): 891–4. doi:10.1097/00001756-199307000-00013. PMID 7690265. 
  4. ^ Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L (October 2004). "A standardized kinesin nomenclature". J. Cell Biol. 167 (1): 19–22. doi:10.1083/jcb.200408113. PMC 2041940. PMID 15479732. 
  5. ^ Cole DG, Chinn SW, Wedaman KP, Hall K, Vuong T, Scholey JM (November 1993). "Novel heterotrimeric kinesin-related protein purified from sea urchin eggs". Nature 366 (6452): 268–70. doi:10.1038/366268a0. PMID 8232586. 
  6. ^ Signor D, Wedaman KP, Rose LS, Scholey JM (February 1999). "Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis elegans". Mol. Biol. Cell 10 (2): 345–60. doi:10.1091/mbc.10.2.345. PMC 25173. PMID 9950681. 
  7. ^ Snow JJ, Ou G, Gunnarson AL, Walker MR, Zhou HM, Brust-Mascher I, Scholey JM (November 2004). "Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons". Nat. Cell Biol. 6 (11): 1109–13. doi:10.1038/ncb1186. PMID 15489852. 
  8. ^ Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ (July 2010). "Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP". Nat. Cell Biol. 12 (7): 703–10. doi:10.1038/ncb2073. PMC 2896429. PMID 20526328. 

Further reading[edit]