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Kinesin family member 1C
Protein KIF1C PDB 2g1l.png
PDB rendering based on 2g1l.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KIF1C ; LTXS1; SATX2; SAX2; SPAX2; SPG58
External IDs OMIM603060 MGI1098260 HomoloGene4821 GeneCards: KIF1C Gene
RNA expression pattern
PBB GE KIF1C 209244 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10749 16562
Ensembl ENSG00000129250 ENSMUSG00000020821
UniProt O43896 O35071
RefSeq (mRNA) NM_006612 NM_153103
RefSeq (protein) NP_006603 NP_694743
Location (UCSC) Chr 17:
4.9 – 4.93 Mb
Chr 11:
70.7 – 70.73 Mb
PubMed search [1] [2]

Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene.[1][2] Kif1C is a fast, non-processive, plus-end directed microtubule motor.[3] Kif1C transports α5β1-integrins in human cells.[4]


KIF1C has been shown to interact with PTPN21[1]and YWHAG.[5]


  1. ^ a b Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R (Sep 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J Biol Chem 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376. 
  2. ^ "Entrez Gene: KIF1C kinesin family member 1C". 
  3. ^ Rogers KR, Weiss S, Crevel I, Brophy PJ, Geeves M, Cross R (September 2001). "KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry". EMBO J. 20 (18): 5101–13. doi:10.1093/emboj/20.18.5101. PMC 125638. PMID 11566875. 
  4. ^ Theisen U, Straube E, Straube A (December 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Dev. Cell 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952. 
  5. ^ Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254. 

Further reading[edit]