KIF22

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Kinesin family member 22
Protein KIF22 PDB 2EDU.png
Rendering based on PDB 2EDU.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KIF22 ; A-328A3.2; KID; KNSL4; OBP; OBP-1; OBP-2; SEMDJL2
External IDs OMIM603213 MGI109233 HomoloGene32011 ChEMBL: 5470 GeneCards: KIF22 Gene
RNA expression pattern
PBB GE KIF22 202183 s at tn.png
PBB GE KIF22 216969 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3835 110033
Ensembl ENSG00000079616 ENSMUSG00000030677
UniProt Q14807 Q3V300
RefSeq (mRNA) NM_001256269 NM_145588
RefSeq (protein) NP_001243198 NP_663563
Location (UCSC) Chr 16:
29.8 – 29.82 Mb
Chr 7:
127.03 – 127.04 Mb
PubMed search [1] [2]

Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene.[1][2][3]

The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in metaphase chromosome alignment and maintenance.[3]

Interactions[edit]

KIF22 has been shown to interact with SIAH1.[4]

Clinical relevance[edit]

Mutations in this gene have been shown to cause developmental disorders such as Spondyloepimetaphyseal dysplasia with joint laxity.[5]

References[edit]

  1. ^ Tokai N, Fujimoto-Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T (April 1996). "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle". EMBO J 15 (3): 457–67. PMC 449964. PMID 8599929. 
  2. ^ Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc Natl Acad Sci U S A 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179. 
  3. ^ a b "Entrez Gene: KIF22 kinesin family member 22". 
  4. ^ Germani A, Bruzzoni-Giovanelli H, Fellous A, Gisselbrecht S, Varin-Blank N, Calvo F (2000). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551. 
  5. ^ Min BJ, Kim N, Chung T, Kim OH, Nishimura G, Chung CY, Song HR, Kim HW, Lee HR, Kim J, Kang TH, Seo ME, Yang SD, Kim DH, Lee SB, Kim JI, Seo JS, Choi JY, Kang D, Kim D, Park WY, Cho TJ (December 2011). "Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type". Am. J. Hum. Genet. 89 (6): 760–6. doi:10.1016/j.ajhg.2011.10.015. PMC 3234366. PMID 22152677. 

Further reading[edit]