KIF3B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Kinesin family member 3B
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KIF3B ; FLA8; HH0048; KLP-11
External IDs OMIM603754 MGI107688 HomoloGene55849 ChEMBL: 6109 GeneCards: KIF3B Gene
EC number 3.6.4.4
RNA expression pattern
PBB GE KIF3B 203943 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9371 16569
Ensembl ENSG00000101350 ENSMUSG00000027475
UniProt O15066 Q61771
RefSeq (mRNA) NM_004798 NM_008444
RefSeq (protein) NP_004789 NP_032470
Location (UCSC) Chr 20:
30.87 – 30.92 Mb
Chr 2:
153.29 – 153.33 Mb
PubMed search [1] [2]

Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene.[1][2]

Function[edit]

The protein encoded by this gene forms a heterotrimeric motor complex with kinesin family member 3A and KAP3 (kinesin accessory protein 3) to drive intra-flagellar transport and possibly to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. The heterotrimeric KIF3B/KIF3A/KAP3 motor protein is a member of the kinesin-2 subfamily of the kinesin superfamily.[2][3][4]

Interactions[edit]

KIF3B has been shown to interact with RAB4A.[5]

References[edit]

  1. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841. 
  2. ^ a b "Entrez Gene: KIF3B kinesin family member 3B". 
  3. ^ Scholey JM (April 1996). "Kinesin-II, a membrane traffic motor in axons, axonemes, and spindles". J. Cell Biol. 133 (1): 1–4. doi:10.1083/jcb.133.1.1. PMC 2120781. PMID 8601599. 
  4. ^ Lawrence, CJ; Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. (2004). "A standardized kinesin nomenclature". Journal of Cell Biology 167: 19–22. doi:10.1083/jcb.200408113. PMC 2041940. PMID 15479732. 
  5. ^ Imamura T, Huang J, Usui I, Satoh H, Bever J, Olefsky JM (July 2003). "Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin". Mol. Cell. Biol. 23 (14): 4892–900. doi:10.1128/MCB.23.14.4892-4900.2003. PMC 162221. PMID 12832475. 

Further reading[edit]