KIR2DL4

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Not to be confused with NKR2B4.
Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
PDB 1efx EBI.jpg
Rendering of KIR2DL4 from PDB 1EFX
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KIR2DL4 ; CD158D; G9P; KIR-103AS; KIR103; KIR103AS
External IDs OMIM604945 HomoloGene124412 GeneCards: KIR2DL4 Gene
RNA expression pattern
PBB GE KIR2DL4 208426 x at tn.png
PBB GE KIR2DL4 211242 x at tn.png
PBB GE KIR2DL4 211245 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3805 n/a
Ensembl ENSG00000189013 n/a
UniProt Q99706 n/a
RefSeq (mRNA) NM_001080770 n/a
RefSeq (protein) NP_001074239 n/a
Location (UCSC) Chr 19:
55.24 – 55.33 Mb
n/a
PubMed search [1] n/a

Killer cell immunoglobulin-like receptor 2DL4 is a protein that in humans is encoded by the KIR2DL4 gene.[1][2]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.[2]

See also[edit]

References[edit]

  1. ^ Selvakumar A, Steffens U, Dupont B (May 1997). "NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains". Tissue Antigens 48 (4 Pt 1): 285–94. doi:10.1111/j.1399-0039.1996.tb02647.x. PMID 8946682. 
  2. ^ a b "Entrez Gene: KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.