KIR2DS4

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Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
Protein KIR2DS4 PDB 1b6u.png
PDB rendering based on 1b6u.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KIR2DS4 ; CD158I; KIR1D; KIR412; KKA3; NKAT8
External IDs OMIM604955 HomoloGene74998 GeneCards: KIR2DS4 Gene
Orthologs
Species Human Mouse
Entrez 3809 n/a
Ensembl ENSG00000221957 n/a
UniProt P43632 n/a
RefSeq (mRNA) NM_012314 n/a
RefSeq (protein) NP_036446 n/a
Location (UCSC) Chr 19:
55.34 – 55.36 Mb
n/a
PubMed search [1] n/a

Killer cell immunoglobulin-like receptor 2DS4 is a protein that in humans is encoded by the KIR2DS4 gene.[1][2][3]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.[3]

See also[edit]

References[edit]

  1. ^ Bottino C, Sivori S, Vitale M, Cantoni C, Falco M, Pende D, Morelli L, Augugliaro R, Semenzato G, Biassoni R, Moretta L, Moretta A (Oct 1996). "A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation". Eur J Immunol 26 (8): 1816–24. doi:10.1002/eji.1830260823. PMID 8765026. 
  2. ^ Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (Jun 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980. 
  3. ^ a b "Entrez Gene: KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.