Killer cell immunoglobulin-like receptor 2DS4 is a protein that in humans is encoded by the KIR2DS4gene.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
^Bottino C, Sivori S, Vitale M, Cantoni C, Falco M, Pende D, Morelli L, Augugliaro R, Semenzato G, Biassoni R, Moretta L, Moretta A (Oct 1996). "A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation". Eur J Immunol26 (8): 1816–24. doi:10.1002/eji.1830260823. PMID8765026.
^Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (Jun 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID7749980.
Katz G, Markel G, Mizrahi S et al. (2001). "Recognition of HLA-Cw4 but not HLA-Cw6 by the NK cell receptor killer cell Ig-like receptor two-domain short tail number 4". J. Immunol.166 (12): 7260–7. PMID11390475.
Hsu KC, Liu XR, Selvakumar A et al. (2002). "Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets". J. Immunol.169 (9): 5118–29. PMID12391228.
Maxwell LD, Wallace A, Middleton D, Curran MD (2003). "A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey". Tissue Antigens60 (3): 254–8. doi:10.1034/j.1399-0039.2002.600307.x. PMID12445308.
Artavanis-Tsakonas K, Eleme K, McQueen KL et al. (2004). "Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes". J. Immunol.171 (10): 5396–405. PMID14607943.
Katz G, Gazit R, Arnon TI et al. (2004). "MHC class I-independent recognition of NK-activating receptor KIR2DS4". J. Immunol.173 (3): 1819–25. PMID15265913.
Yen JH, Lin CH, Tsai WC et al. (2006). "Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis". Scand. J. Rheumatol.35 (2): 124–7. doi:10.1080/03009740500381252. PMID16641046.