KIR2DS4

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Killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
Protein KIR2DS4 PDB 1b6u.png
PDB rendering based on 1b6u.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KIR2DS4 ; CD158I; KIR1D; KIR412; KKA3; NKAT8
External IDs OMIM604955 HomoloGene74998 GeneCards: KIR2DS4 Gene
Orthologs
Species Human Mouse
Entrez 3809 n/a
Ensembl ENSG00000221957 n/a
UniProt P43632 n/a
RefSeq (mRNA) NM_012314 n/a
RefSeq (protein) NP_036446 n/a
Location (UCSC) Chr 19:
55.34 – 55.36 Mb
n/a
PubMed search [1] n/a

Killer cell immunoglobulin-like receptor 2DS4 is a protein that in humans is encoded by the KIR2DS4 gene.[1][2][3]

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.[3]

See also[edit]

References[edit]

  1. ^ Bottino C, Sivori S, Vitale M, Cantoni C, Falco M, Pende D, Morelli L, Augugliaro R, Semenzato G, Biassoni R, Moretta L, Moretta A (Oct 1996). "A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation". Eur J Immunol 26 (8): 1816–24. doi:10.1002/eji.1830260823. PMID 8765026. 
  2. ^ Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati MS, Vitale M, Bottino C, Moretta L, Moretta A, Long EO (Jun 1995). "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains". Immunity 2 (5): 439–49. doi:10.1016/1074-7613(95)90025-X. PMID 7749980. 
  3. ^ a b "Entrez Gene: KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4". 

Further reading[edit]

  • Döhring C, Samaridis J, Colonna M (1996). "Alternatively spliced forms of human killer inhibitory receptors". Immunogenetics 44 (3): 227–30. doi:10.1007/BF02602590. PMID 8662091. 
  • Kim J, Chwae YJ, Kim MY et al. (1997). "Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors". J. Immunol. 159 (8): 3875–82. PMID 9378975. 
  • Campbell KS, Cella M, Carretero M et al. (1998). "Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complex". Eur. J. Immunol. 28 (2): 599–609. doi:10.1002/(SICI)1521-4141(199802)28:02<599::AID-IMMU599>3.0.CO;2-F. PMID 9521070. 
  • Chwae YJ, Cho SE, Kim SJ, Kim J (1999). "Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual". Immunol. Lett. 68 (2–3): 267–74. doi:10.1016/S0165-2478(99)00062-0. PMID 10424431. 
  • Fan QR, Long EO, Wiley DC (2000). "Cobalt-mediated dimerization of the human natural killer cell inhibitory receptor". J. Biol. Chem. 275 (31): 23700–6. doi:10.1074/jbc.M003318200. PMID 10816589. 
  • Rajalingam R, Gardiner CM, Canavez F et al. (2001). "Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors". Tissue Antigens 57 (1): 22–31. doi:10.1034/j.1399-0039.2001.057001022.x. PMID 11169255. 
  • Katz G, Markel G, Mizrahi S et al. (2001). "Recognition of HLA-Cw4 but not HLA-Cw6 by the NK cell receptor killer cell Ig-like receptor two-domain short tail number 4". J. Immunol. 166 (12): 7260–7. PMID 11390475. 
  • Hsu KC, Liu XR, Selvakumar A et al. (2002). "Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets". J. Immunol. 169 (9): 5118–29. PMID 12391228. 
  • Maxwell LD, Wallace A, Middleton D, Curran MD (2003). "A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey". Tissue Antigens 60 (3): 254–8. doi:10.1034/j.1399-0039.2002.600307.x. PMID 12445308. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Artavanis-Tsakonas K, Eleme K, McQueen KL et al. (2004). "Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes". J. Immunol. 171 (10): 5396–405. PMID 14607943. 
  • Maxwell LD, Williams F, Gilmore P et al. (2005). "Investigation of killer cell immunoglobulin-like receptor gene diversity: II. KIR2DS4". Hum. Immunol. 65 (6): 613–21. doi:10.1016/j.humimm.2004.02.028. PMID 15219381. 
  • Katz G, Gazit R, Arnon TI et al. (2004). "MHC class I-independent recognition of NK-activating receptor KIR2DS4". J. Immunol. 173 (3): 1819–25. PMID 15265913. 
  • Yen JH, Lin CH, Tsai WC et al. (2006). "Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis". Scand. J. Rheumatol. 35 (2): 124–7. doi:10.1080/03009740500381252. PMID 16641046. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.