KIR3DL2

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Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KIR3DL2 ; CD158K; NKAT-4; NKAT4; NKAT4B; p140
External IDs OMIM604947 HomoloGene129622 GeneCards: KIR3DL2 Gene
Orthologs
Species Human Mouse
Entrez 3812 245615
Ensembl ENSG00000167633 ENSMUSG00000057439
UniProt P43630 n/a
RefSeq (mRNA) NM_001242867 NM_177748
RefSeq (protein) NP_001229796 NP_808416
Location (UCSC) Chr 19:
55.24 – 55.38 Mb
Chr X:
136.45 – 136.54 Mb
PubMed search [1] [2]

Killer cell immunoglobulin-like receptor 3DL2 is a protein that in humans is encoded by the KIR3DL2 gene.[1][2][3] Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.[3]

See also[edit]

References[edit]

  1. ^ Colonna M, Samaridis J (May 1995). "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells". Science 268 (5209): 405–8. doi:10.1126/science.7716543. PMID 7716543. 
  2. ^ Dohring C, Samaridis J, Colonna M (Aug 1996). "Alternatively spliced forms of human killer inhibitory receptors". Immunogenetics 44 (3): 227–30. doi:10.1007/BF02602590. PMID 8662091. 
  3. ^ a b "Entrez Gene: KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.