Kin of IRRE-like protein 1, also known as NEPH1, is a protein that in humans is encoded by the KIRRELgene.
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (KIRREL2, MIM607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766). NEPH1 is expressed in filtration slits of kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration of blood (Sellin et al., 2003).[supplied by OMIM]
Huber TB, Schmidts M, Gerke P, et al. (2003). "The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1.". J. Biol. Chem.278 (15): 13417–21. doi:10.1074/jbc.C200678200. PMID12578837.
Barletta GM, Kovari IA, Verma RK, et al. (2003). "Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers.". J. Biol. Chem.278 (21): 19266–71. doi:10.1074/jbc.M301279200. PMID12646566.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem.76 (10): 2763–72. doi:10.1021/ac035352d. PMID15144186.
Kitamura A, Tsukaguchi H, Iijima K, et al. (2007). "Genetics and clinical features of 15 Asian families with steroid-resistant nephrotic syndrome.". Nephrol. Dial. Transplant.21 (11): 3133–8. doi:10.1093/ndt/gfl347. PMID16968734.