KLC1

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Kinesin light chain 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KLC1 ; KLC; KNS2; KNS2A
External IDs OMIM600025 MGI107978 HomoloGene4056 GeneCards: KLC1 Gene
RNA expression pattern
PBB GE KNS2 212878 s at tn.png
PBB GE KNS2 212877 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3831 16593
Ensembl ENSG00000126214 ENSMUSG00000021288
UniProt Q07866 O88447
RefSeq (mRNA) NM_001130107 NM_001025358
RefSeq (protein) NP_001123579 NP_001020529
Location (UCSC) Chr 14:
104.03 – 104.15 Mb
Chr 12:
111.76 – 111.81 Mb
PubMed search [1] [2]

Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene.[1][2][3]

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.[3]

Interactions[edit]

KLC1 has been shown to interact with MAPK8IP3,[2] KIF5B[4][5][6] and KIF5A.[5][6]

References[edit]

  1. ^ Cabeza-Arvelaiz Y, Shih LC, Hardman N, Asselbergs F, Bilbe G, Schmitz A, White B, Siciliano MJ, Lachman LB (Feb 1994). "Cloning and genetic characterization of the human kinesin light-chain (KLC) gene". DNA Cell Biol 12 (10): 881–92. doi:10.1089/dna.1993.12.881. PMID 8274221. 
  2. ^ a b Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Jan 2001). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729. 
  3. ^ a b "Entrez Gene: KNS2 kinesin 2". 
  4. ^ Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry (United States) 41 (50): 14906–15. doi:10.1021/bi026417u. ISSN 0006-2960. PMID 12475239. 
  5. ^ a b Rahman, A; Friedman D S; Goldstein L S (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. (UNITED STATES) 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. ISSN 0021-9258. PMID 9624122. 
  6. ^ a b Rahman, A; Kamal A; Roberts E A; Goldstein L S (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". J. Cell Biol. (UNITED STATES) 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. ISSN 0021-9525. PMC 2156125. PMID 10491391. 

Further reading[edit]