KLC2

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Kinesin light chain 2
Protein KLC2 PDB 3CEQ.png
Rendering based on PDB 3CEQ.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KLC2 ; FLJ12387
External IDs OMIM611729 MGI107953 HomoloGene22468 GeneCards: KLC2 Gene
RNA expression pattern
PBB GE KLC2 218906 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 64837 16594
Ensembl ENSG00000174996 ENSMUSG00000024862
UniProt Q9H0B6 Q91YS4
RefSeq (mRNA) NM_001134774 NM_008451
RefSeq (protein) NP_001128246 NP_032477
Location (UCSC) Chr 11:
66.02 – 66.04 Mb
Chr 19:
5.11 – 5.12 Mb
PubMed search [1] [2]

Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene.[1][2]


Interactions[edit]

KLC2 has been shown to interact with MAPK8IP3[3] and KIF5B.[1][4]

Model organisms[edit]

Model organisms have been used in the study of KLC2 function. A conditional knockout mouse line called Klc2tm1e(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]



References[edit]

  1. ^ a b Rahman A, Friedman DS, Goldstein LS (July 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J Biol Chem 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. PMID 9624122. 
  2. ^ "Entrez Gene: KLC2 kinesin light chain 2". 
  3. ^ Bowman, A B; Kamal A; Ritchings B W; Philp A V; McGrail M; Gindhart J G; Goldstein L S (November 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell (UNITED STATES) 103 (4): 583–94. doi:10.1016/S0092-8674(00)00162-8. ISSN 0092-8674. PMID 11106729. 
  4. ^ Rahman, A; Kamal A; Roberts E A; Goldstein L S (September 1999). "Defective Kinesin Heavy Chain Behavior in Mouse Kinesin Light Chain Mutants". J. Cell Biol. (UNITED STATES) 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. ISSN 0021-9525. PMC 2156125. PMID 10491391. 
  5. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  6. ^ a b "International Mouse Phenotyping Consortium". 
  7. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  8. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  9. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  10. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  11. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]