KLK10

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Kallikrein-related peptidase 10
Identifiers
Symbols KLK10 ; NES1; PRSSL1
External IDs OMIM602673 MGI1916790 HomoloGene26428 ChEMBL: 4180 GeneCards: KLK10 Gene
EC number 3.4.21.35
RNA expression pattern
PBB GE KLK10 209792 s at tn.png
PBB GE KLK10 215808 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5655 69540
Ensembl ENSG00000129451 ENSMUSG00000030693
UniProt O43240 Q99M20
RefSeq (mRNA) NM_001077500 NM_133712
RefSeq (protein) NP_001070968 NP_598473
Location (UCSC) Chr 19:
51.52 – 51.52 Mb
Chr 7:
43.78 – 43.79 Mb
PubMed search [1] [2]

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.[1][2][3][4][5]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.[5]

References[edit]

  1. ^ Liu XL, Wazer DE, Watanabe K, Band V (Sep 1996). "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression". Cancer Res 56 (14): 3371–9. PMID 8764136. 
  2. ^ Polikoff D, Kuo WL, Cochran JF, Wernick M, Kowbel D, Myambo K, Collins CC (Apr 1998). "Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping". Cytogenet Cell Genet 79 (1-2): 147–8. doi:10.1159/000134705. PMID 9533035. 
  3. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  4. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  5. ^ a b "Entrez Gene: KLK10 kallikrein-related peptidase 10". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.246