KLK13

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Kallikrein-related peptidase 13
Identifiers
Symbols KLK13 ; KLK-L4; KLKL4
External IDs OMIM605505 MGI3615275 HomoloGene56714 ChEMBL: 4863 GeneCards: KLK13 Gene
RNA expression pattern
PBB GE KLK13 217315 s at tn.png
PBB GE KLK13 205783 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26085 626834
Ensembl ENSG00000167759 ENSMUSG00000054046
UniProt Q9UKR3 Q8CGR6
RefSeq (mRNA) NM_015596 NM_001039042
RefSeq (protein) NP_056411 NP_001034131
Location (UCSC) Chr 19:
51.56 – 51.57 Mb
Chr 7:
43.71 – 43.73 Mb
PubMed search [1] [2]

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.[1][2][3]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined.[3]

References[edit]

  1. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  2. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  3. ^ a b "Entrez Gene: KLK13 kallikrein-related peptidase 13". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.306