KLK14

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Kallikrein-related peptidase 14
Identifiers
Symbols KLK14 ; KLK-L6
External IDs OMIM606135 MGI2447564 HomoloGene69348 ChEMBL: 2641 GeneCards: KLK14 Gene
RNA expression pattern
PBB GE KLK14 220573 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 43847 317653
Ensembl ENSG00000129437 ENSMUSG00000044737
UniProt Q9P0G3 Q8CGR5
RefSeq (mRNA) NM_022046 NM_174866
RefSeq (protein) NP_071329 NP_777355
Location (UCSC) Chr 19:
51.58 – 51.59 Mb
Chr 7:
43.69 – 43.7 Mb
PubMed search [1] [2]

Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.[1][2][3]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. An additional transcript variant has been described but its full length nature has not been determined.[3]

References[edit]

  1. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  2. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  3. ^ a b "Entrez Gene: KLK14 kallikrein-related peptidase 14". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.029