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Kallikrein-related peptidase 2
Symbols KLK2 ; KLK2A2; hGK-1; hK2
External IDs OMIM147960 MGI892019 HomoloGene124422 IUPHAR: 2372 ChEMBL: 2442 GeneCards: KLK2 Gene
EC number
RNA expression pattern
PBB GE KLK2 209854 s at tn.png
PBB GE KLK2 209855 s at tn.png
PBB GE KLK2 210339 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3817 16623
Ensembl ENSG00000167751 ENSMUSG00000063133
UniProt P20151 Q8C232
RefSeq (mRNA) NM_001002231 NM_010645
RefSeq (protein) NP_001002231 NP_034775
Location (UCSC) Chr 19:
51.36 – 51.38 Mb
Chr 7:
43.83 – 43.84 Mb
PubMed search [1] [2]

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.[1][2][3][4]


  1. ^ Riegman PH, Vlietstra RJ, Klaassen P, van der Korput JA, Geurts van Kessel A, Romijn JC, Trapman J (May 1989). "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19". FEBS Lett 247 (1): 123–126. doi:10.1016/0014-5793(89)81253-0. PMID 2468530. 
  2. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. 
  3. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–636. doi:10.1515/BC.2006.081. PMID 16800723. 
  4. ^ "Entrez Gene: KLK2 Kallikrein-related peptidase 2". 

Further reading[edit]

  • Riegman PH; Vlietstra RJ; van der Korput HA et al. (1992). "Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species". Mol. Cell. Endocrinol. 76 (1–3): 181–190. doi:10.1016/0303-7207(91)90272-T. PMID 1726490. 
  • Qin H; Kemp J; Yip MY et al. (1992). "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization". Hum. Hered. 41 (4): 222–226. doi:10.1159/000154005. PMID 1783409. 
  • Schedlich LJ, Bennetts BH, Morris BJ (1988). "Primary structure of a human glandular kallikrein gene". DNA 6 (5): 429–437. doi:10.1089/dna.1987.6.429. PMID 2824146. 
  • Frenette G; Deperthes D; Tremblay RR et al. (1997). "Purification of enzymatically active kallikrein hK2 from human seminal plasma". Biochim. Biophys. Acta 1334 (1): 109–15. doi:10.1016/s0304-4165(96)00080-3. PMID 9042371. 
  • Bourgeois L; Brillard-Bourdet M; Deperthes D et al. (1997). "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2". J. Biol. Chem. 272 (47): 29590–29595. doi:10.1074/jbc.272.47.29590. PMID 9368023. 
  • Mikolajczyk SD, Millar LS, Kumar A, Saedi MS (1998). "Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors". Prostate 34 (1): 44–50. doi:10.1002/(SICI)1097-0045(19980101)34:1<44::AID-PROS6>3.0.CO;2-K. PMID 9428387. 
  • Yu DC, Sakamoto GT, Henderson DR (1999). "Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy". Cancer Res. 59 (7): 1498–504. PMID 10197620. 
  • Mikolajczyk SD, Millar LS, Kumar A, Saedi MS (1999). "Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1". Int. J. Cancer 81 (3): 438–442. doi:10.1002/(SICI)1097-0215(19990505)81:3<438::AID-IJC18>3.0.CO;2-U. PMID 10209959. 
  • Lövgren J; Valtonen-André C; Marsal K et al. (1999). "Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluids". J. Androl. 20 (3): 348–55. PMID 10386814. 
  • Cargill M; Altshuler D; Ireland J et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231–238. doi:10.1038/10290. PMID 10391209. 
  • Lövgren J, Airas K, Lilja H (1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". Eur. J. Biochem. 262 (3): 781–789. doi:10.1046/j.1432-1327.1999.00433.x. PMID 10411640. 
  • Mikolajczyk SD; Millar LS; Marker KM et al. (1999). "Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue". Cancer Res. 59 (16): 3927–30. PMID 10463585. 
  • Liu XF; Essand M; Vasmatzis G et al. (1999). "Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing". Biochem. Biophys. Res. Commun. 264 (3): 833–839. doi:10.1006/bbrc.1999.1595. PMID 10544017. 
  • Ren F; Zhang S; Mitchell SH et al. (2000). "Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells". Oncogene 19 (15): 1924–1932. doi:10.1038/sj.onc.1203511. PMID 10773882. 
  • Harvey TJ; Hooper JD; Myers SA et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–37406. doi:10.1074/jbc.M004525200. PMID 10969073. 
  • Chen VC, Chao L, Chao J (2001). "A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein". J. Biol. Chem. 275 (51): 40371–40377. doi:10.1074/jbc.M005691200. PMID 10991942. 
  • Gan L; Lee I; Smith R et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene 257 (1): 119–130. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574. 
  • Réhault S; Monget P; Mazerbourg S et al. (2001). "Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3". Eur. J. Biochem. 268 (10): 2960–2968. doi:10.1046/j.1432-1327.2001.02185.x. PMID 11358513. 
  • Saedi MS; Zhu Z; Marker K et al. (2002). "Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells". Int. J. Cancer 94 (4): 558–563. doi:10.1002/ijc.1501. PMID 11745444. 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.161