KLK6

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Kallikrein-related peptidase 6
Protein KLK6 PDB 1gvl.png
PDB rendering based on 1gvl.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KLK6 ; Bssp; Klk7; PRSS18; PRSS9; SP59; hK6
External IDs OMIM602652 MGI1343166 HomoloGene68279 ChEMBL: 4448 GeneCards: KLK6 Gene
EC number 3.4.21.-
RNA expression pattern
PBB GE KLK6 204733 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5653 19144
Ensembl ENSG00000167755 ENSMUSG00000050063
UniProt Q92876 O88301
RefSeq (mRNA) NM_001012964 NM_001164696
RefSeq (protein) NP_001012982 NP_001158168
Location (UCSC) Chr 19:
51.46 – 51.47 Mb
Chr 7:
43.82 – 43.83 Mb
PubMed search [1] [2]

Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene.[1][2][3][4]

Function[edit]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.[4]

References[edit]

  1. ^ Yamashiro K, Tsuruoka N, Kodama S, Tsujimoto M, Yamamura Y, Tanaka T, Nakazato H, Yamaguchi N (Feb 1997). "Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain". Biochim Biophys Acta 1350 (1): 11–4. doi:10.1016/s0167-4781(96)00187-x. PMID 9003450. 
  2. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  3. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  4. ^ a b "Entrez Gene: KLK6 kallikrein-related peptidase 6". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.236