KLK8

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Kallikrein-related peptidase 8
KLK8.png
Identifiers
Symbols KLK8 ; HNP; NP; NRPN; PRSS19; TADG14
External IDs OMIM605644 MGI1343327 HomoloGene21410 ChEMBL: 4812 GeneCards: KLK8 Gene
EC number 3.4.21.118
Orthologs
Species Human Mouse
Entrez 11202 259277
Ensembl ENSG00000129455 ENSMUSG00000064023
UniProt O60259 Q61955
RefSeq (mRNA) NM_001281431 NM_008940
RefSeq (protein) NP_001268360 NP_032966
Location (UCSC) Chr 19:
51.5 – 51.51 Mb
Chr 7:
43.8 – 43.8 Mb
PubMed search [1] [2]

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.[1][2][3][4][5]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.[5]

References[edit]

  1. ^ Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N (May 1999). "A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain". Eur J Biochem 260 (3): 627–34. doi:10.1046/j.1432-1327.1999.00213.x. PMID 10102990. 
  2. ^ Yoshida S, Taniguchi M, Hirata A, Shiosaka S (Aug 1998). "Sequence analysis and expression of human neuropsin cDNA and gene". Gene 213 (1–2): 9–16. doi:10.1016/S0378-1119(98)00232-7. PMID 9714609. 
  3. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  4. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  5. ^ a b "Entrez Gene: KLK8 kallikrein-related peptidase 8". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.244