NKG2-C type II integral membrane protein is a protein that in humans is encoded by the KLRC2gene.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.
^Lazetic, S; Chang C; Houchins J P; Lanier L L; Phillips J H (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". J. Immunol. (UNITED STATES) 157 (11): 4741–5. ISSN0022-1767. PMID8943374.
Glienke J, Sobanov Y, Brostjan C et al. (1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex". Immunogenetics48 (3): 163–73. doi:10.1007/s002510050420. PMID9683661.
Ding Y, Sumitran S, Holgersson J (1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scand. J. Immunol.49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID10320637.
Khakoo SI, Rajalingam R, Shum BP et al. (2000). "Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans". Immunity12 (6): 687–98. doi:10.1016/S1074-7613(00)80219-8. PMID10894168.
Shum BP, Flodin LR, Muir DG et al. (2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes". J. Immunol.168 (1): 240–52. PMID11751968.
Hikami K, Tsuchiya N, Yabe T, Tokunaga K (2003). "Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population". Genes Immun.4 (2): 160–7. doi:10.1038/sj.gene.6363940. PMID12618865.
Miyashita R, Tsuchiya N, Hikami K et al. (2004). "Molecular genetic analyses of human NKG2C (KLRC2) gene deletion". Int. Immunol.16 (1): 163–8. doi:10.1093/intimm/dxh013. PMID14688071.
Gumá M, Busch LK, Salazar-Fontana LI et al. (2005). "The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells". Eur. J. Immunol.35 (7): 2071–80. doi:10.1002/eji.200425843. PMID15940674.