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Killer cell lectin-like receptor subfamily C, member 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KLRC2 ; CD159c; NKG2-C; NKG2C
External IDs OMIM602891 HomoloGene135919 GeneCards: KLRC2 Gene
RNA expression pattern
PBB GE KLRC2 206785 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3822 n/a
Ensembl ENSG00000205809 n/a
UniProt P26717 n/a
RefSeq (mRNA) NM_002260 n/a
RefSeq (protein) NP_002251 n/a
Location (UCSC) Chr 12:
10.58 – 10.59 Mb
PubMed search [1] n/a

NKG2-C type II integral membrane protein is a protein that in humans is encoded by the KLRC2 gene.[1][2]

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.[2]


KLRC2 has been shown to interact with KLRD1.[3][4]

See also[edit]


  1. ^ Plougastel B, Trowsdale J (Aug 1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes". Genomics 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306. 
  2. ^ a b "Entrez Gene: KLRC2 killer cell lectin-like receptor subfamily C, member 2". 
  3. ^ Lazetic, S; Chang C; Houchins J P; Lanier L L; Phillips J H (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". J. Immunol. (UNITED STATES) 157 (11): 4741–5. ISSN 0022-1767. PMID 8943374. 
  4. ^ Ding, Y; Sumitran S; Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scand. J. Immunol. (ENGLAND) 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. ISSN 0300-9475. PMID 10320637. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.