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Killer cell lectin-like receptor subfamily C, member 4
Symbols KLRC4 ; NKG2-F; NKG2F
External IDs OMIM602893 HomoloGene49341 GeneCards: KLRC4 Gene
Species Human Mouse
Entrez 8302 n/a
Ensembl ENSG00000183542 n/a
UniProt O43908 n/a
RefSeq (mRNA) NM_013431 n/a
RefSeq (protein) NP_038459 n/a
Location (UCSC) Chr 12:
10.56 – 10.56 Mb
PubMed search [1] n/a

NKG2-F type II integral membrane protein is a protein that in humans is encoded by the KLRC4 gene.[1][2]

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC4 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The 3' end of the KLRC4 transcript includes the first non-coding exon found at the 5' end of the adjacent D12S2489E gene transcript.[2]


  1. ^ Plougastel B, Trowsdale J (Aug 1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes". Genomics 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306. 
  2. ^ a b "Entrez Gene: KLRC4 killer cell lectin-like receptor subfamily C, member 4". 

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