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Kringle containing transmembrane protein 1
External IDs OMIM609898 MGI1933988 HomoloGene12935 GeneCards: KREMEN1 Gene
Species Human Mouse
Entrez 83999 84035
Ensembl ENSG00000183762 ENSMUSG00000020393
UniProt Q96MU8 Q99N43
RefSeq (mRNA) NM_001039570 NM_032396
RefSeq (protein) NP_001034659 NP_115772
Location (UCSC) Chr 22:
29.47 – 29.56 Mb
Chr 11:
5.19 – 5.26 Mb
PubMed search [1] [2]

Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene.[1][2]

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.[2]


  1. ^ Nakamura T, Aoki S, Kitajima K, Takahashi T, Matsumoto K, Nakamura T (Mar 2001). "Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein". Biochim Biophys Acta 1518 (1-2): 63–72. doi:10.1016/s0167-4781(01)00168-3. PMID 11267660. 
  2. ^ a b "Entrez Gene: KREMEN1 kringle containing transmembrane protein 1". 

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