The Broadcasting Department of the University's College of Journalism and Mass Communications operates the radio station. It is managed by faculty of the Broadcasting Department. Most of the staff are students who are majoring in broadcasting.
KRNU offers many genres of music, but airs mostly indie rock and experimental rock music. Officially, it is General Format programming. Some of the other genres that are played include: Jazz, Folk, Rap, and A Cappella. There are also sports talk programs and play-by-play programs of Nebraska Cornhuskers home sporting events.
On Friday, August 17, 2009, the station launched "The New 90.3 KRNU". These changes feature a tighter rotation of independent and local artists and bands, along with less specialty show programming. The old format will continue as the web station "KRNU 2", and will feature all of the specialty shows that are not on the new "on-air" format.