The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.
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^Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol174 (2): 169–74. doi:10.1083/jcb.200603161. PMC2064177. PMID16831889.
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Rogers MA, Winter H, Langbein L et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". J. Invest. Dermatol.114 (3): 464–72. doi:10.1046/j.1523-1747.2000.00910.x. PMID10692104.
Langbein L, Rogers MA, Winter H et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem.274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID10391933.
Rogers MA, Winter H, Langbein L et al. (1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5". J. Invest. Dermatol.107 (4): 633–8. doi:10.1111/1523-1747.ep12584243. PMID8823373.