For decades, KWKW played various forms of Spanish-language music on AM 1300. In the mid-1990s, KWKW traded licences and therefore frequencies with KAZN and this moved KWKW onto the 1330 frequency. The station started to focus on Mexican regional music (including mariachi and banda) and called itself "La Mexicana."
In 2004, KWKW stopped playing music and began all-sports programming in an alliance with ESPN Deportes Radio, a brand of the ESPN sports empire. The station still airs some non-sports programs on a time brokerage basis on Sunday nights.
The station has also carried the last two FIFA World Cups. In 2010, KWKW interrupted its normal Spanish-language feed to carry most of ESPN Radio's English-language coverage. These games will be in the preliminary rounds, when ESPN Radio puts the games on an alternate feed to the usual talk radio lineup. This also allows KSPN and KLAA to continue with their normal program schedules. (Some weekend games and the final will be carried on KSPN, while a daily recap show airs on KLAA.) The 2006 coverage was in Spanish.
The Dodgers left KWKW, their Spanish-language broadcast home for most of its history, for KHJ effective with the 2008 season. Instead, the station carries the Los Angeles Angels and the Galaxy.
The station also simulcasts on KWKU, 1220AM in Pomona, California. KWKU has broken from the simulcast on occasion, most notably in the early 2000s when it was the radio station carrier of the Los Angeles Sparks of the WNBA. It also carries a secondary feed of a team bumped from KWKW due to conflicts.