Kanangra Creek (officially designated as a river) rises near Mount Wallarra, below the Boyd Plateau on the western slopes of Mount Thurat, and flows generally south-east and north-east through Kanangra Gorge, joined by one minor tributary, before reaching its confluence with the Coxs River at Konangaroo Clearing. The river descends 950 metres (3,120 ft) over its 20 kilometres (12 mi) course. The river is entirely contained within the world heritage-listed Kanangra-Boyd National Park.
The Kanangra-Boyd Wilderness is among the largest and most rugged wilderness areas in New South Wales. Situated to the south of Katoomba in the Blue Mountains and the Kanangra-Boyd National Parks, this folded belt or "Rim Rock" area is markedly different from the Permo-Triassicsandstone dominated landforms which comprise the rest of the Blue Mountains. The Kanangra Gorge, along the river floor, is cut 600–900 metres (2,000–3,000 ft) deep in rocks of the Lambie Group, and is one of Australia's deepest gorges.