The M10 begins north of Karachi at the end of Mohammad Ali Jinnah Road, near the junction of the M9 to which it is connected through a Trumpet interchange. It then continues north for a few kilometers before turning west, where it forms an interchange with the N25. After this interchange it eventually turns south back towards Karachi and merges onto the KPT Flyover at Karachi Port.
On September 1st 2007, a bridge collapsed in Karachi along the Karachi Northern Bypass which had opened in August 2007 in which 6 people were killed. Karachi's mayor said the bridge was built by the state-run National Highway Authority and officially opened by President Pervez Musharraf.