Karel Otčenášek (13 April 1920 – 23 May 2011) was a Czech prelate of the Roman Catholic Church.
Otčenášek was born in České Meziříčí, Czech Republic and was ordained a priest on 17 March 1945. He became Apostolic Administrator of the Diocese of Hradec Králové on 30 March 1950 and was consecrated bishop on 30 April 1950. From 1951 to 1962 he was imprisoned for having been consecrated without the consent of the government which was legally required during the communist rule of the Czechoslovakia. Otcenášek was appointed bishop of the Diocese of Hradec Králové on 21 December 1989, where he served until his retirement on 6 June 1998.
He was promoted Archbishop ad personam by John Paul II. on 24 September 1998.