Karl Anton Hickel (1745 – October 30, 1798) was an 18th-century painter.
Hickel was born in Český Krumlov, Bohemia, and enrolled in the Academy of Fine Arts Vienna in Vienna, Austria in 1758. After graduation, he worked as a painter under his brother, Joseph Hickel, who was also a painter. Beginning in 1779, he served as a traveling portrait painter. He spent considerable time in Munich where he painted Charles Theodore, Elector of Bavaria, among others. He then traveled in southern Germany, Switzerland, then to Mannheim and Mainz. He moved to Switzerland in 1785, and then became the official court painter of Joseph II, Holy Roman Emperor. In 1786, he travelled to France where he painted under the patronage of Marie Antoinette and Marie-Louise, princesse de Lamballe. He died in Hamburg.