The locality was created in the course of the dewatering of the Donaumooses begun at 1790 in the year 1795 as colony of Karl baron v. kind of hitting a corner. The place was until 1840 seat of an aristocracy yard Mark (and/or a Patrimonialgerichts). 1804 had five times more originally planned it already over 300 inhabitants - than. The living conditions were in particular in the start time very hard and improved in the course of the decades only little. 1824 were created a little later again a closed spinning mill, 1898 developed the moorland laboratory. 1888 gave it already 1,227 inhabitants. The place kept courses of a distressed area, until the Second World War like in many places a fundamental upswing began.
Today Karlshuld is a prosperierende municipality, which won in the last years also as residence - not least due to the proximity to Ingolstadt - at attractiveness.
In the years 1970 to 1985 took place the incorporations of the municipality parts Grasheim, Kochheim, Nazibühl and Neuschwetzingen.