Karyopherin

From Wikipedia, the free encyclopedia
Jump to: navigation, search

Karyopherins are a group of proteins involved in transporting molecules between the cytoplasm and the nucleus of a eukaryotic cell. The inside of the nucleus is called the karyoplasm (or nucleoplasm). Generally, karyopherin-mediated transport occurs through the nuclear pore, which acts as a gateway into and out of the nucleus. Most proteins require karyopherins to traverse the nuclear pore.

Karyopherins can act as importins (i.e. helping proteins get into the nucleus) or exportins (i.e. helping proteins get out of the nucleus). They belong to The Nuclear Pore Complex Family[1] in the transporter classification database (TCDB).

Energy for transport is derived from the Ran gradient. See Ran for further details.

Importin beta[edit]

Importin beta is a specific type of karyopherin that facilitates the transport of cargo proteins into the nucleus. First, it is binding importin alpha - another type of karyopherin that binds the cargo protein in the cytoplasm - before the cargo protein is imported into the nucleus through the nuclear pore using energy derived from the Ran gradient. Once inside the nucleus, the cargo dissociates from the karyopherins.

Importin beta can also carry proteins into the nucleus without the aid of the importin alpha adapter protein.[2]

Human genes in the karyopherin family[edit]

Additional images[edit]

References[edit]

  1. ^ http://www.tcdb.org/search/result.php?tc=9.A.14
  2. ^ Poon, I. K. H. and D. A. Jans (2005). "Regulation of nuclear transport: Central role in development and transformation?" Traffic 6(3): 173-186.

External links[edit]



⇐⊗□□□⌈ℚℚℚ≤