Currie's paintings are primarily concerned with how the human body is affected by illness, ageing and physical injury. Closely related to these themes, his work also deals with social and political issues and philosophical questions. Although many of the images dealing with metaphysical questions do not feature figures, a human presence is nevertheless suggested.[how?]
His Glasgow History Mural was commissioned on the 200th anniversary of the Calton weavers Massacre in 1987 and is displayed on the ceiling of the People's Palace.
Currie was commissioned by the University of Edinburgh to paint a portrait of Peter Higgs, the theoretical physicist, which was unveiled in 2009. He is a "reluctant portraitist", and this was only his second portrait. He said, referring to the Higgs boson, "I am very interested in Peter's work. I don't for one second claim to grasp the theory, but I do understand the sublime, and there is a sublime quality to it all, a beauty, an awesome quality. In some respects, the subject is quite terrifying."