Keratin 12

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Keratin 12
Identifiers
Symbols KRT12 ; K12
External IDs OMIM601687 MGI96687 HomoloGene188 GeneCards: KRT12 Gene
Orthologs
Species Human Mouse
Entrez 3859 268482
Ensembl ENSG00000187242 ENSMUSG00000020912
UniProt Q99456 Q64291
RefSeq (mRNA) NM_000223 NM_010661
RefSeq (protein) NP_000214 NP_034791
Location (UCSC) Chr 17:
39.02 – 39.02 Mb
Chr 11:
99.42 – 99.42 Mb
PubMed search [1] [2]

Keratin 12 is a protein that in humans is encoded by the KRT12 gene.[1][2]

Keratin 12 is keratin found expressed in corneal epithelia. Mutations in the gene encoding this protein lead to Meesmann corneal dystrophy.[1]

References[edit]

  1. ^ a b Irvine AD, Corden LD, Swensson O, Swensson B, Moore JE, Frazer DG, Smith FJ, Knowlton RG, Christophers E, Rochels R, Uitto J, McLean WH (June 1997). "Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy". Nat. Genet. 16 (2): 184–7. doi:10.1038/ng0697-184. PMID 9171831. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 

Further reading[edit]