Keratin 5

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Keratin 5
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KRT5 ; CK5; DDD; EBS2; K5; KRT5A
External IDs OMIM148040 MGI96702 HomoloGene55461 GeneCards: KRT5 Gene
RNA expression pattern
PBB GE KRT5 201820 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3852 110308
Ensembl ENSG00000186081 ENSMUSG00000061527
UniProt P13647 Q922U2
RefSeq (mRNA) NM_000424 NM_027011
RefSeq (protein) NP_000415 NP_081287
Location (UCSC) Chr 12:
52.91 – 52.91 Mb
Chr 15:
101.71 – 101.71 Mb
PubMed search [1] [2]

Keratin, type II cytoskeletal 5 also known as KRT5 is a protein that in human is encoded by the KRT5 gene.[1][2][3]

Function[edit]

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic (i.e., different types of) keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. The type II cytokeratin genes are clustered in a region of chromosome 12q12-q13.

This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14.

Clinical significance[edit]

Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex.[4] In lung cancer affecting the proximal airways, stem cells that express keratin 5 are likely to be affected cell line.[5]

Interactions[edit]

Keratin 5 has been shown to interact with ALOX12.[6]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: KRT5 keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)". 
  2. ^ Lersch R, Fuchs E (January 1988). "Sequence and expression of a type II keratin, K5, in human epidermal cells". Mol. Cell. Biol. 8 (1): 486–93. PMC 363157. PMID 2447486. 
  3. ^ Eckert RL, Rorke EA (June 1988). "The sequence of the human epidermal 58-kD (#5) type II keratin reveals an absence of 5' upstream sequence conservation between coexpressed epidermal keratins". DNA 7 (5): 337–45. doi:10.1089/dna.1.1988.7.337. PMID 2456903. 
  4. ^ Schuilenga-Hut PH, Vlies P, Jonkman MF, Waanders E, Buys CH, Scheffer H (April 2003). "Mutation analysis of the entire keratin 5 and 14 genes in patients with epidermolysis bullosa simplex and identification of novel mutations". Hum. Mutat. 21 (4): 447. doi:10.1002/humu.9124. PMID 12655565. 
  5. ^ Mulvihill, MS; Kratz JR; Pham P (February 2013). "The role of stem cells in airway repair: implications for the origins of lung cancer". Chinese Journal of Cancer 32 (2): 71–74. doi:10.5732/cjc.012.10097. PMC 3845611. PMID 23114089. 
  6. ^ Tang, K; Finley; Finley R L, Nie D, Honn K V (March 2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry (UNITED STATES) 39 (12): 3185–91. doi:10.1021/bi992664v. ISSN 0006-2960. PMID 10727209. 

Further reading[edit]

External links[edit]