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Keratinocytes)
The keratinocyte is the major constituent of the epidermis, constituting 95% of the cells found there.[1] Those keratinocytes found in the stratum basale are sometimes referred to as "basal cells" or "basal keratinocytes."[2]
Melanosomes are transferred to it by dendritic processes(Cytocrine melanin).
Keratinocytes form tight junctions with the nerves of the skin and hold the Langerhans cells and intra-dermal lymphocytes in position within the epidermis. Keratinocytes are essential immunomodulaters, maintaining the intergrity of the immune response by secreting inhibitory cytokines such as IL-4 and TGFβ when dormant, but when provoked, the keratinocytes will stimulate cutaneous inflammation and Langerhan cell activation via THFα and IL-1β secretion.
[edit] References
- ^ McGrath, J.A.; Eady, R.A.; Pope, F.M. (2004). Rook's Textbook of Dermatology (Seventh Edition). Blackwell Publishing. Pages 3.7. ISBN 9780632064298.
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. Pages 5-6. ISBN 0721629210.
