|Classification and external resources|
Keratoglobus (from Greek: kerato- horn, cornea; and globus round), is a degenerative non-inflammatory disorder of the eye in which structural changes within the cornea cause it to become extremely thin and change to a more globular shape than its normal gradual curve. It causes corneal thinning, primarily at the margins, resulting in a spherical, slightly enlarged eye.
It is sometimes equated with "megalocornea".
It is a much rarer condition than keratoconus, which is the most common dystrophy of the cornea. Similar to keratoconus it is typically diagnosed in the patient's adolescent years and attains its most severe state in the twenties and thirties.
Keratoglobus is a little-understood disease with an uncertain cause, and its progression following diagnosis is unpredictable. If afflicting both eyes, the deterioration in vision can affect the patient's ability to drive a car or read normal print. It does not however lead to blindness per se.
Keratoglobus continues to be a somewhat mysterious disease, but it can be successfully managed with a variety of clinical and surgical techniques. The patient is at risk for globe perforation because the thinned out cornea is extremely weak.
Because of the similarities with keratoconus (degenerative deformation and thinning of the cornea), the same conservative surgery could be used in early stages in order to reinforce the cornea. Methods include Intrastromal corneal ring segments, Mini Asymmetric Radial Keratotomy (M.A.R.K.) and Cross-linking.
Further progression of the disease usually leads to a need for corneal transplantation because of extreme thinning of the cornea. Primarily, large size penetrating keratoplasty has been advocated. Recent additions of techniques specifically for keratoglobus include the "tuck procedure", whereby a 12 mm corneo-scleral donor graft is taken and trimmed at its outer edges. A host pocket is formed at the limbal margin and the donor tissue is "tucked" into the host pocket.
- "keratoglobus" at Dorland's Medical Dictionary
- Kaushal S, Jhanji V, Sharma N, Tandon R, Titiyal JS, Vajpayee RB (February 2008). ""Tuck In" Lamellar Keratoplasty (TILK) for corneal ectasias involving corneal periphery". Br J Ophthalmol 92 (2): 286–90. doi:10.1136/bjo.2007.124628. PMID 18227208.