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Keratohyalin is associated with eleidin, the intermediate between keratohyalin and keratin; histological location is in the stratum lucidum, thick skin.
In the stratum granulosum, the "grainy" third layer of the human epidermis, the protein Keratohyalin forms dense cytoplasmic granules that promote dehydration of the cell as well as aggregation and cross-linking of the keratin fibers. The nuclei and other organelles then disintegrate, and the cells die. Further dehydration creates a tightly interlocked layer of cells that consists of keratin fibers surrounded by keratohyalin.
- Wheater's Functional Histology, 5th ed. Young, Lowe, Stevens and Heath.
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