Ketazocine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ketazocine
Ketazocine structure.svg
Systematic (IUPAC) name
(2S,6R,11R)-3-(cyclopropylmethyl)-8-hydroxy-6,11-dimethyl-3,4,5,6-tetrahydro-2,6-methano-3-benzazocin-1(2H)-one
Clinical data
Legal status ?
Routes Oral
Identifiers
CAS number 36292-69-0 YesY
ATC code None
PubChem CID 3054741
ChemSpider 2316328 YesY
UNII 6IO4IG518S YesY
KEGG D04649 YesY
Chemical data
Formula C18H23NO2 
Mol. mass 285.38 g/mol
 YesY (what is this?)  (verify)

Ketazocine (INN), also known as ketocyclazocine, is a benzomorphan derivative used in opioid receptor research. Ketocyclazocine is an exogenous opioid that binds to the kappa opioid receptor.[1]

Activation of this receptor causes a decrease in pain sensations and increased sleepiness but can also cause psychological symptoms such as dysphoria, paranoia, and hallucinations. It also causes an increase in urine production because it inhibits the release of vasopressin. (Vasopressin is an endogenous substance that assists in regulating fluid and electrolyte balance in the body and decreases the amount of water released into the urine.)

Unlike other opioids, substances that only bind to the kappa receptor theoretically do not depress the respiratory system.

See also[edit]

References[edit]

  1. ^ Leander JD (Sep 1982). "Effects of ketazocine, ethylketazocine and phenazocine on schedule-controlled behavior: antagonism by naloxone". Neuropharmacology 21 (9): 923–8. doi:10.1016/0028-3908(82)90085-5. PMID 6128693.