Ketotifen
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Ketotifen
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| Systematic (IUPAC) name | |
| 4-(1-methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one | |
| Identifiers | |
| CAS number | |
| ATC code | R06 S01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C19H19NOS |
| Mol. mass | 309.426 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 60% |
| Protein binding | 75% |
| Metabolism | Hepatic |
| Half life | 12 Hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
?(US) Oral - Prescription, Eye Drops - OTC |
| Routes | Oral, Eye Drops |
Ketotifen fumarate (ophthalmic solutions marketed under the brand name Zaditor (Novartis) and Alaway (Bausch and Lomb)) is an H1-antihistamine/mast cell stabilizer available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. In its oral form, it is used to prevent asthma attacks. Side effects include drowsiness, weight gain, dry mouth, irritability, and increased nosebleeds.
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[edit] General Information
Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under 3. The mean elimination half life is 12 hours.[1]
[edit] Recreational Use
Ketotifen is used to up-regulate Beta-2 adrenergic receptors down-regulated by Beta-2 adrenergic agonists such as the drug Clenbuterol (often used in body-building communities).[citation needed]
[edit] References
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This article includes a list of references, related reading or external links, but its sources remain unclear because it lacks inline citations. Please improve this article by introducing more precise citations where appropriate. (June 2009) |
- ^ Grahnén A; Lönnebo A, Beck O, Eckernäs SA, Dahlström B, Lindström B (May 1992). "Pharmacokinetics of ketotifen after oral administration to healthy male subjects". Biopharm Drug Dispos 13 (4): 255–62. doi:. PMID 1600111.
[edit] External links
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