4-(1-Methylpiperidin-4-ylidene)-4,9-dihydro-10 H-benzo[4,5]cyclohepta[1,2- b]thiophen-10-one
Micromedex Detailed Consumer Information
Pregnancy cat. C
Legal status Oral - Prescription; Eye Drops - OTC
Routes Oral, Eye Drops
Protein binding 75%
Half-life 12 Hours
R06 AX17 S01 GX08
C 19 H 19 N O S
Mol. mass 309.426 g/mol
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Ketotifen is a second-generation noncompetitive H 1- antihistamine and mast cell stabilizer. It is most commonly sold as a salt with fumaric acid, ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy [1 ] red eyes caused by allergies. In its oral form, it is used to prevent asthma attacks.
Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under three.
The mean elimination half life is 12 hours. [1 ] Besides its anti-histaminic activity, it is also a functional [2 ] leukotriene antagonist and a phosphodiesterase inhibitor.
The drug may also help relieve the symptoms of
irritable bowel syndrome. [3 ]
Side effects [ edit ]
Side effects include drowsiness, weight gain, dry mouth, irritability, and increased nosebleeds.
Ketotifen is marketed as ophthalmic solutions under the brand names
Zaditor, Zaditen, [4 ] Alaway, Zyrtec Itchy-Eye Drops, and Claritin Eye. A generic version of Novartis' Zaditor, ketotifen fumarate ophthalmic solution, 0.025%, is available. Generic Zaditor is made by Alcon Laboratories Apotex, Inc.and Akorn, Inc.
Bausch & Lomb makes a brand-name version (Alaway®) that is equivalent to Zaditor.
See also [ edit ]
References [ edit ]
^ a b Zaditor prescribing information Novartis
^ Grahnén A; Lönnebo A; Beck O; Eckernäs SA; Dahlström B; Lindström B (May 1992). "Pharmacokinetics of ketotifen after oral administration to healthy male subjects". Biopharm Drug Dispos 13 (4): 255–262. doi: 10.1002/bdd.2510130404. PMID 1600111.
^ Klooker, TK; Braak, B; Koopman, KE; Welting, O; Wouters, MM; Van Der Heide, S; Schemann, M; Bischoff, SC et al. (2010). "The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome". Gut 59 (9): 1213–21. doi: 10.1136/gut.2010.213108. PMID 20650926.
^ Novartis Pharmaceuticals, Alphabetically, beginning with Z.
External links [ edit ]
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