The drug is marketed as ophthalmic solutions under the brand names Zaditor/Zaditen (Novartis),Alaway (Bausch and Lomb), Zyrtec Itchy-Eye Drops, and Claritin Eye. A generic version of Novartis' Zaditor, ketotifen fumarate ophthalmic solution, 0.025%, is available from Perrigo[clarification needed] and distributed as store brands, such as Eye Itch Relief from Walgreens.
Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under three. The mean elimination half life is 12 hours. Besides its anti-histaminic activity, it is also a functional leukotriene antagonist and a phosphodiesterase inhibitor. The drug may also help relieve the symptoms of Irritable bowel syndrome.
^Grahnén A; Lönnebo A, Beck O, Eckernäs SA, Dahlström B, Lindström B (May 1992). "Pharmacokinetics of ketotifen after oral administration to healthy male subjects". Biopharm Drug Dispos13 (4): 255–262. doi:10.1002/bdd.2510130404. PMID1600111.Cite uses deprecated parameters (help)
^Klooker, TK; Braak, B; Koopman, KE; Welting, O; Wouters, MM; Van Der Heide, S; Schemann, M; Bischoff, SC et al. (2010). "The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome". Gut59 (9): 1213–21. doi:10.1136/gut.2010.213108. PMID20650926.