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Khadem (Arabic: خادم) is a given name and surname; it may refer to:
- Khadem al-Qubaisi (born 1971), Emirati managing director of the IPIC
- Abdelaziz Belkhadem (born 1945), Algerian politician
- Ali Khademhosseini (born 1975), Iranian-Canadian bioengineer
- Amir Reza Khadem (born 1970), Iranian wrestler
- Dhikru'llah Khadem (1904–1986), Iranian Hand of the Cause
- Mohammad Khadem (born 1935), Iranian wrestler
- Rasoul Khadem (born 1972), Iranian wrestler
- Samir El-Khadem (born 1942), Lebanese former Commander of the Lebanese Naval Forces
- Khademabad, village in Razaviyeh District, Mashhad County, Iran
- Khadem Anlu, village in Chapeshlu District, Dargaz County, Iran
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