Kikori lies in the delta of the Kikori River at the head of the Gulf of Papua. This area is particularly biologically rich with a diversity of ecosystems and densely forested, with an intricate system of rivers. The geography is that of limestone karst country, with clay type soils. Oil exploitation in Kikori has been operating for several years. Its first commercial oil deposits were found there by the Kutubu Joint Venture (KJV) which has since constructed a pipeline to the Gulf of Papua and is actively extracting oil from the region.
It has an average annual rainfall of about 584 centimetres (230 inches). It is the site of Kikori Airport.